Haemolytic anaemia: a consequence of COVID-19

BMJ Case Rep. 2020 Dec 10;13(12):e238118. doi: 10.1136/bcr-2020-238118.

Abstract

A man in his early 50s presented with jaundice, mild shortness of breath on exertion and dark urine. He had had coryzal symptoms 2 weeks prior to admission. Medical history included obstructive sleep apnoea and hypertension. His initial blood tests showed a mild hyperbilirubinaemia and acute kidney injury stage 1. Chest X-ray and CT pulmonary angiogram were negative for features suggestive of COVID-19. He later developed a drop in haemoglobin and repeat bloods showed markedly raised lactate dehydrogenase and positive direct antiglobulin test. These results were felt to be consistent with a haemolytic anaemia. A nasopharyngeal swab came back positive for COVID-19. We suspect the cause of his symptoms was an autoimmune haemolytic anaemia secondary to COVID-19 which has recently been described in European cohorts.

Keywords: haematology (incl blood transfusion); infections.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic, Autoimmune / diagnosis*
  • Anemia, Hemolytic, Autoimmune / etiology*
  • COVID-19 / complications
  • COVID-19 / diagnosis*
  • COVID-19 Testing*
  • Chest Pain / etiology
  • Hemoglobinuria / etiology
  • Humans
  • Jaundice / etiology
  • Male
  • Middle Aged