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    Mol Cell Biol. 1987 Dec;7(12):4564-7.

    Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

    Schleuning WD, Medcalf RL, Hession C, Rothenbühler R, Shaw A, Kruithof EK.

    Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.

    We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

    PMID: 3325828 [PubMed - indexed for MEDLINE]

    PMCID: PMC368144

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