Noncoding RNA, Intragenomic Conflict, and Rodent SRY Evolution

Scott William Roy

doi:10.1016/j.tig.2020.11.004

Noncoding RNA, Intragenomic Conflict, and Rodent SRY Evolution

Trends Genet. 2021 Feb;37(2):102-104. doi: 10.1016/j.tig.2020.11.004. Epub 2020 Nov 23.

Author

Scott William Roy¹

Affiliation

¹ San Francisco State University, 1600 Holloway Ave, San Francisco, CA 94132, USA. Electronic address: scottwroy@gmail.com.

PMID: 33243450
DOI: 10.1016/j.tig.2020.11.004

Abstract

The sex-determining gene SRY has undergone rapid evolution in rodents. Curiously, a new study by Miyawaki et al. reveals that a recently evolved SRY gene sequence antagonizes SRY protein stability, necessitating splicing of a novel intron. Other data suggest that this troublesome gene region has noncoding RNA functions, possibly related to conflict between sex chromosomes.

MeSH terms

Amino Acid Sequence
Animals
Evolution, Molecular
Genes, sry / genetics*
Genome / genetics*
Introns / genetics
Phylogeny
RNA, Untranslated / genetics*
Rodentia / genetics*
Sex Chromosomes / genetics
Sex Determination Processes / genetics*

Substances

RNA, Untranslated