Preoperative successful thrombectomy and thrombolysis of acute extensive splanchnic venous system and TIPSS thrombosis in a child with Budd-Chiari syndrome-Creating a window to enable living donor liver transplantation

Pediatr Transplant. 2021 May;25(3):e13857. doi: 10.1111/petr.13857. Epub 2020 Nov 24.

Abstract

Preoperative extensive PV thrombosis can pose a technical challenge during liver transplantation surgery. Several strategies adopted to mitigate this problem include creation of a superior mesenteric vein-PV jump graft, use of a polytetrafluoroethylene graft, renoportal anastomosis, or cavoportal hemitransposition. Extensive and diffuse thrombosis of the splanchnic venous system may even necessitate multivisceral transplantation. We describe the case of a pediatric patient with Budd-Chiari syndrome and decompensated cirrhosis, who developed extensive thrombosis of the porto-spleno-mesenteric venous system prior to liver transplantation. We used a combination technique of thrombus aspiration by a novel trans-TIPPS approach followed by thrombolysis. Complete preoperative resolution of the extensive thrombosis was achieved. This allowed the creation of a brief window to enable planned LDLT. In prudently selected patients, performing an early mechanical and chemical thrombolysis of an extensive acute splanchnic venous thrombosis can thus help expedite a planned LDLT.

Keywords: Budd-Chiari Syndrome; acute extensive splanchnic venous system thrombosis; hepatopulmonary syndrome; living donor liver transplantation; pediatric liver transplantation; thrombectomy and thrombolysis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Budd-Chiari Syndrome / surgery*
  • Child
  • Combined Modality Therapy
  • Humans
  • Liver Transplantation*
  • Living Donors
  • Male
  • Portal Vein*
  • Portasystemic Shunt, Transjugular Intrahepatic*
  • Postoperative Complications / therapy*
  • Preoperative Period
  • Splenic Vein*
  • Thrombectomy*
  • Thrombolytic Therapy*
  • Treatment Outcome
  • Venous Thrombosis / therapy*
  • Viscera / blood supply*