Diagnosis and treatment of lymphomas in the era of epigenetics

Alain Chebly; Eliane Chouery; Joana Ropio; Hampig Raphael Kourie; Marie Beylot-Barry; Jean-Philippe Merlio; Roland Tomb; Edith Chevret

doi:10.1016/j.blre.2020.100782

Diagnosis and treatment of lymphomas in the era of epigenetics

Blood Rev. 2021 Jul:48:100782. doi: 10.1016/j.blre.2020.100782. Epub 2020 Nov 17.

Authors

Alain Chebly¹, Eliane Chouery², Joana Ropio³, Hampig Raphael Kourie⁴, Marie Beylot-Barry⁵, Jean-Philippe Merlio⁶, Roland Tomb⁷, Edith Chevret⁸

Affiliations

¹ Bordeaux University, INSERM U1053 Bordeaux Research in Translational Oncology (BaRITOn), Cutaneous Lymphoma Oncogenesis Team, F-33000 Bordeaux, France; Saint Joseph University, Faculty of Medicine, Medical Genetics Unit (UGM), Beirut, Lebanon.
² Saint Joseph University, Faculty of Medicine, Medical Genetics Unit (UGM), Beirut, Lebanon.
³ Bordeaux University, INSERM U1053 Bordeaux Research in Translational Oncology (BaRITOn), Cutaneous Lymphoma Oncogenesis Team, F-33000 Bordeaux, France; Porto University, Institute of Biomedical Sciences of Abel Salazar, 4050-313 Porto, Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Institute of Molecular Pathology and Immunology (Ipatimup), Cancer Biology group, 4200-465 Porto, Portugal.
⁴ Saint Joseph University, Faculty of Medicine, Medical Genetics Unit (UGM), Beirut, Lebanon; Saint Joseph University, Faculty of Medicine, Hematology-Oncology Department, Beirut, Lebanon.
⁵ Bordeaux University, INSERM U1053 Bordeaux Research in Translational Oncology (BaRITOn), Cutaneous Lymphoma Oncogenesis Team, F-33000 Bordeaux, France; Bordeaux University Hospital Center, Dermatology Department, 33000 Bordeaux, France.
⁶ Bordeaux University, INSERM U1053 Bordeaux Research in Translational Oncology (BaRITOn), Cutaneous Lymphoma Oncogenesis Team, F-33000 Bordeaux, France; Bordeaux University Hospital Center, Tumor Bank and Tumor Biology Laboratory, 33600 Pessac, France.
⁷ Saint Joseph University, Faculty of Medicine, Medical Genetics Unit (UGM), Beirut, Lebanon; Saint Joseph University, Faculty of Medicine, Dermatology Department, Beirut, Lebanon.
⁸ Bordeaux University, INSERM U1053 Bordeaux Research in Translational Oncology (BaRITOn), Cutaneous Lymphoma Oncogenesis Team, F-33000 Bordeaux, France. Electronic address: edith.chevret@u-bordeaux.fr.

PMID: 33229141
DOI: 10.1016/j.blre.2020.100782

Abstract

Lymphomas represent a heterogeneous group of cancers characterized by clonal lymphoproliferation. Over the past decades, frequent epigenetic dysregulations have been identified in hematologic malignancies including lymphomas. Many of these impairments occur in genes with established roles and well-known functions in the regulation and maintenance of the epigenome. In hematopoietic cells, these dysfunctions can result in abnormal DNA methylation, erroneous chromatin state and/or altered miRNA expression, affecting many different cellular functions. Nowadays, it is evident that epigenetic dysregulations in lymphoid neoplasms are mainly caused by genetic alterations in genes encoding for enzymes responsible for histone or chromatin modifications. We summarize herein the recent epigenetic modifiers findings in lymphomas. We focus also on the most commonly mutated epigenetic regulators and emphasize on actual epigenetic therapies.

Keywords: DNA methylation; Epigenetic therapy; Epigenetics; Histone modification; Lymphoma; miRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chromatin / genetics
Chromatin / metabolism
Combined Modality Therapy
DNA Methylation
Disease Management
Disease Susceptibility
Epigenesis, Genetic / drug effects
Epigenomics / methods
Gene Expression Regulation, Neoplastic / drug effects
Histone Code / drug effects
Histones / metabolism
Humans
Lymphoma / diagnosis*
Lymphoma / genetics
Lymphoma / mortality
Lymphoma / therapy*
Treatment Outcome

Substances

Chromatin
Histones