A controlled comparison of fluoxetine and amitript...[Br J Psychiatry. 1987]

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1: Br J Psychiatry. 1987 Sep;151:337-40.Links

A controlled comparison of fluoxetine and amitriptyline in depressed out-patients.

Young JP, Coleman A, Lader MH.

St Thomas's Hospital, London.

Fluoxetine, a selective serotonin uptake inhibitor (mean dose 73 mg each morning) was compared with amitriptyline (mean dose 122 mg at night) in a double-blind study of 64 depressed out-patients. Fifty patients completed the 6-week trial. The drugs did not differ with respect to psychiatrists' ratings, but amitriptyline was slightly superior with respect to patients' ratings. The amitriptyline-treated group had complaints of dry mouth and dizziness on standing; the fluoxetine-treated group of sleep disturbances, nausea, and headaches.

PMID: 3322468 [PubMed - indexed for MEDLINE]

A comparative trial of fluoxetine and amitriptyline in patients with major depressive disorder.
J Clin Psychiatry. 1985 Sep; 46(9):369-72.

[J Clin Psychiatry. 1985]
A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder.
J Clin Psychiatry. 1985 Mar; 46(3 Pt 2):32-7.

[J Clin Psychiatry. 1985]
Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression.
J Clin Psychopharmacol. 1988 Apr; 8(2):112-5.

[J Clin Psychopharmacol. 1988]
ReviewA controlled trial of amitriptyline and cianopramine in major depression.
Clin Ther. 1985; 7(6):699-703.

[Clin Ther. 1985]
ReviewFluoxetine: prescribing guidelines for the newest antidepressant.
South Med J. 1989 Aug; 82(8):1005-9.

[South Med J. 1989]
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Cited by 3 PubMed Central articles

Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis.
Trindade E, Menon D, Topfer LA, Coloma C. CMAJ. 1998 Nov 17; 159(10):1245-52.

[CMAJ. 1998]
Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.
Song F, Freemantle N, Sheldon TA, House A, Watson P, Long A, Mason J. BMJ. 1993 Mar 13; 306(6879):683-7.

[BMJ. 1993]
Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis.
Anderson IM, Tomenson BM. BMJ. 1995 Jun 3; 310(6992):1433-8.

[BMJ. 1995]

Patient Drug Information

Amitriptyline (Limbitrol® (as a combination product containing amitriptyline and chlordiazepoxide), Limbitrol® DS (as a combination product containing amitriptyline and chlordiazepoxide))
Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are n...
Fluoxetine (Prozac® , Prozac® Weekly, Sarafem® , ...)
Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...
Bupropion (Wellbutrin, Wellbutrin, Wellbutrin XL, ...)
How do the newer antidepressants compare in treating depression?
Source: AHFS Consumer Medication Information

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Cited by 3 PubMed Central articles

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