Lead exposure and its association with cardiovascular disease and diabetic kidney disease in middle-aged and elderly diabetic patients

Aims: Previous studies have suggested that a high blood lead level (BLL) is associated with cardiovascular outcomes and impaired renal function in the general population; however, studies investigating the effect of a high BLL on diabetic vascular complications have been limited. We aimed to investigate whether a higher BLL is associated with cardiovascular disease (CVD) and diabetic kidney disease (DKD).

Methods: We analyzed 4234 individuals out of 4813 diabetic participants enrolled from seven communities in China in 2018 in this cross-sectional study. Macrovascular measurements, including assessment of common carotid artery (CCA) plaques and their diameters, were performed with ultrasound. CVD was defined as a composite measure including a previous diagnosis of coronary heart disease, myocardial infarction, or stroke. The definition of DKD was an albumin to creatinine ratio (ACR) ≥30 mg/g or an estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m². Linear and logistic regression analyses were used to measure the associations.

Results: The median age and BLL of the participants were 67 years (interquartile range, 62-72 years) and 26 μg/L (interquartile range, 18-36 μg/L). Compared with the first quartile, the odds ratio (OR) (95% CI) of CCA plaques ranging from none to bilateral in the ordinal logistic regression analysis associated with BLL was 1.53 (1.29, 1.82) in the fourth BLL quartile (P for trend <0.01), and the odds of having CVD was significantly increased by 44% for participants in the fourth quartile (1.44 (1.17, 1.76)) (P for trend <0.01). The odds of DKD in the fourth BLL quartile increased by 36% (1.36 (1.06, 1.74)) compared with that in the first quartile (P for trend <0.05). These associations were adjusted for potential confounders.

Conclusions: A high BLL may be a potential risk factor for CVD and DKD in middle-aged and elderly diabetic adults.