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1: FEBS Lett. 1987 Dec 10;225(1-2):201-4.Click here to read Links

Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation.

Bocckino SB, Wilson PB, Exton JH.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232.

Vasopressin, angiotensin II and epinephrine elicited the accumulation of phosphatidylethanol in rat hepatocytes exposed to ethanol and of phosphatidate in the absence of ethanol. When isolated liver plasma membranes were exposed to ethanol, GTP gamma S stimulated the production of phosphatidylethanol whereas phosphatidate was formed in the absence of ethanol. With increasing ethanol concentrations, phosphatidate formation declined whereas phosphatidylethanol production increased. These findings suggest that rat hepatocytes possess a hormone-dependent phospholipase D activity that can also catalyze the formation of phosphatidylethanol.

PMID: 3319693 [PubMed - indexed for MEDLINE]