Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling

Irene Voldsbekk; Inge Groote; Nathalia Zak; Daniël Roelfs; Oliver Geier; Paulina Due-Tønnessen; Lise-Linn Løkken; Marie Strømstad; Taran Y Blakstvedt; Yvonne S Kuiper; Torbjørn Elvsåshagen; Lars T Westlye; Atle Bjørnerud; Ivan I Maximov

doi:10.1016/j.neuroimage.2020.117540

Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling

Neuroimage. 2021 Feb 1:226:117540. doi: 10.1016/j.neuroimage.2020.117540. Epub 2020 Nov 10.

Authors

Affiliations

¹ Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway. Electronic address: irene.voldsbekk@psykologi.uio.no.
² Computational Radiology and Artificial Intelligence (CRAI), Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
³ Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁴ Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁵ Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
⁶ Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
⁷ Department of Psychology, University of Oslo, Oslo, Norway.
⁸ Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway.
⁹ Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway.
¹⁰ Department of Psychology, University of Oslo, Oslo, Norway; Computational Radiology and Artificial Intelligence (CRAI), Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Department of Physics, University of Oslo, Oslo, Norway.
¹¹ Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway; Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway. Electronic address: ivan.maximov@psykologi.uio.no.

PMID: 33186715
DOI: 10.1016/j.neuroimage.2020.117540

Abstract

Sleep deprivation influences several critical functions, yet how it affects human brain white matter (WM) is not well understood. The aim of the present work was to investigate the effect of 32 hours of sleep deprivation on WM microstructure compared to changes observed in a normal sleep-wake cycle (SWC). To this end, we utilised diffusion weighted imaging (DWI) including the diffusion tensor model, diffusion kurtosis imaging and the spherical mean technique, a novel biophysical diffusion model. 46 healthy adults (23 sleep deprived vs 23 with normal SWC) underwent DWI across four time points (morning, evening, next day morning and next day afternoon, after a total of 32 hours). Linear mixed models revealed significant group × time interaction effects, indicating that sleep deprivation and normal SWC differentially affect WM microstructure. Voxel-wise comparisons showed that these effects spanned large, bilateral WM regions. These findings provide important insight into how sleep deprivation affects the human brain.

Keywords: DWI; MRI; Sleep; Sleep deprivation; Structural plasticity; White matter.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / diagnostic imaging
Brain / pathology*
Diffusion Tensor Imaging / methods*
Female
Humans
Image Interpretation, Computer-Assisted
Male
Sleep / physiology
Sleep Deprivation / diagnostic imaging
Sleep Deprivation / pathology*
White Matter / diagnostic imaging
White Matter / pathology*