The importance of early use of beta blockers and gastric decontamination in caffeine overdose: A case report

Aust Crit Care. 2021 Jul;34(4):395-400. doi: 10.1016/j.aucc.2020.09.007. Epub 2020 Oct 31.

Abstract

Caffeine is a common stimulant consumed daily worldwide and available in a wide variety of over-the-counter formulations. It is a mild central nervous system stimulant when used in recommended doses. However, it can be fatal if taken as an intentional or accidental overdose. We report a case of a 48-year-old lady with depression and post-traumatic stress disorder who consumed a significant overdose of caffeine, triggered by the stress that she had contracted coronavirus disease 19. This led to significant cardiovascular and central nervous system toxicity. The condition was identified early and managed appropriately with early β-blockers and gastric decontamination, which saved her life. There are few studies with regard to such modalities on treatment for caffeine overdose; our patient responded rapidly and favourably to the treatment. Why should an emergency physician be aware of this? Caffeine overdose is uncommon but one that clinicians should be aware of. Early identification and intervention with β-adrenergic antagonists and activated charcoal is paramount in caffeine toxicity.

Keywords: Activated charcoal; COVID-19; Caffeine; Overdose; SARS-CoV-2; β-blockers.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • COVID-19 / psychology
  • Caffeine / poisoning*
  • Drug Overdose / therapy*
  • Female
  • Gastric Lavage / methods*
  • Humans
  • Middle Aged
  • SARS-CoV-2

Substances

  • Adrenergic beta-Antagonists
  • Caffeine