Ann N Y Acad Sci. 1987;498:186-99.

Interaction of ascorbate and alpha-tocopherol.

Abstract

Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vitamin E by reducing vitamin E radicals formed when vitamin E scavenges the oxygen radicals. This interaction between vitamin C and vitamin E radicals can take place not only in homogeneous solutions but also in liposomal membrane systems where vitamins C and E reside separately outside and within the membranes respectively, and vitamin C can act as a synergist.

PMID:: 3304060; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Lipid antioxidants: how they may act in biological systems. [Br J Cancer Suppl. 1987]
Review Lipid antioxidants: how they may act in biological systems.
Niki E. Br J Cancer Suppl. 1987 Jun; 8:153-7.
The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes. [Chem Phys Lipids. 1990]
The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes.
van den Berg JJ, Kuypers FA, Roelofsen B, Op den Kamp JA. Chem Phys Lipids. 1990 Mar; 53(4):309-20.
Review The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. [Arch Biochem Biophys. 1993]
Review The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.
Buettner GR. Arch Biochem Biophys. 1993 Feb 1; 300(2):535-43.
Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin. [Free Radic Res Commun. 1992]
Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin.
Kagan V, Witt E, Goldman R, Scita G, Packer L. Free Radic Res Commun. 1992; 16(1):51-64.
Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. [Biochem Pharmacol. 1992]
Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals.
Kagan VE, Shvedova A, Serbinova E, Khan S, Swanson C, Powell R, Packer L. Biochem Pharmacol. 1992 Oct 20; 44(8):1637-49.

See reviews... See all...

Cited by 11 PubMed Central articles

Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. [Front Genet. 2012]
Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e.
Boddupalli S, Mein JR, Lakkanna S, James DR. Front Genet. 2012; 3:7. Epub 2012 Jan 24.
An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network. [PLoS One. 2010]
An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network.
Jacobs H, Moalin M, Bast A, van der Vijgh WJ, Haenen GR. PLoS One. 2010 Nov 8; 5(11):e13880. Epub 2010 Nov 8.
Ascorbic acid protects against restraint stress-induced memory deficits in Wistar rats. [Clinics (Sao Paulo). 2009]
Ascorbic acid protects against restraint stress-induced memory deficits in Wistar rats.
Kumar RS, Narayanan SN, Nayak S. Clinics (Sao Paulo). 2009; 64(12):1211-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Interaction of ascorbate and alpha-tocopherol.
Interaction of ascorbate and alpha-tocopherol.
Ann N Y Acad Sci. 1987 ;498:186-99.

PubMed
The sp-I genes in the Balbiani rings of Chironomus salivary glands.
The sp-I genes in the Balbiani rings of Chironomus salivary glands.
Results Probl Cell Differ. 1987 ;14:69-80.

PubMed
Carbohydrate taste, appetite, and obesity: an overview.
Carbohydrate taste, appetite, and obesity: an overview.
Neurosci Biobehav Rev. 1987 Summer ;11(2):131-53.

PubMed
[Application of lasers in biometry and diagnosis].
[Application of lasers in biometry and diagnosis].
Nihon Rinsho. 1987 Apr ;45(4):720-8.

PubMed
Topical minoxidil in male pattern baldness: effects of discontinuation of treatm...
Topical minoxidil in male pattern baldness: effects of discontinuation of treatment.
J Am Acad Dermatol. 1987 Jul ;17(1):97-101.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Interaction of ascorbate and alpha-tocopherol.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information