Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection

Huaqiang Tao; Gaoran Ge; Wenming Li; Xiaolong Liang; Hongzhi Wang; Ning Li; Houyi Sun; Wei Zhang; Dechun Geng

doi:10.1016/j.mehy.2020.110332

Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection

Med Hypotheses. 2020 Dec:145:110332. doi: 10.1016/j.mehy.2020.110332. Epub 2020 Oct 6.

Authors

Huaqiang Tao¹, Gaoran Ge¹, Wenming Li¹, Xiaolong Liang¹, Hongzhi Wang¹, Ning Li¹, Houyi Sun¹, Wei Zhang¹, Dechun Geng²

Affiliations

¹ Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
² Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215000, China. Electronic address: szgengdc@suda.edu.cn.

Abstract

At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Given the growing cases of COVID-19, analyzing the relevance between COVID-19 and fragile patients who suffer from bone destruction is entirely indispensable. Accordingly, the recapitulatory commentary is necessary to advance our knowledge on COVID-19 and orthopedics. In this article, we particularly clarify the possible relationship between the newly COVID-19 infection and bone lesions from the standpoints of dysimmunity and inflammatory storm.

Keywords: Bone lesions; COVID-19; Dysimmunity; Inflammatory storm; SARS-CoV-2.

MeSH terms

Bone Diseases / pathology
Bone Diseases / virology*
Bone and Bones / pathology
COVID-19 / physiopathology*
Cytokines / blood*
Humans
Hypoxia*
Immune System Diseases / physiopathology
Inflammation / physiopathology*
Models, Theoretical
Orthopedics
Osteoblasts / cytology
Osteoclasts / cytology
Risk Factors

Substances

Cytokines