Human parvovirus 4: An emerging etiological agent in cases presenting with influenza like illness

J Med Virol. 2021 Aug;93(8):5158-5162. doi: 10.1002/jmv.26579. Epub 2021 Apr 6.

Abstract

This study was planned to study the association of parvovirus 4 (PARV4) with Influenza-like illness (ILI). A total of 1111 patients with a clinical diagnosis of ILI and 220 healthy controls were tested for Influenza A/HINI/and H3N2, Influenza B, and PARV4. Further sequencing was done to analyze the genotype distribution of parvovirus 4. Influenza A/HINI, A/H3N2, and B were detected in 334 (30.06%), 9 (0.81%), and 10 (0.9%) cases respectively. PARV4 was detected in 135 (12.15%) cases and one healthy control. Parvovirus 4 was significantly higher in cases as compared to controls (relative risk, 30.77%; p < .0006). Sequencing of 20 isolates suggests the dominance of genotype 2 in our region.

Keywords: Parvovirus 4; disease association; genotype; influenza like illness (ILI); influenza virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coinfection / epidemiology
  • Coinfection / virology
  • Genotype
  • Humans
  • India / epidemiology
  • Influenza A virus / genetics
  • Influenza A virus / isolation & purification
  • Influenza B virus / genetics
  • Influenza B virus / isolation & purification
  • Influenza, Human / epidemiology
  • Influenza, Human / virology
  • Parvoviridae Infections / epidemiology
  • Parvoviridae Infections / virology*
  • Parvovirus / genetics
  • Parvovirus / isolation & purification*
  • Prevalence
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / virology*
  • Risk