Recent progress on nanoparticles for targeted aneurysm treatment and imaging

Nisakorn Yodsanit; Bowen Wang; Yi Zhao; Lian-Wang Guo; K Craig Kent; Shaoqin Gong

doi:10.1016/j.biomaterials.2020.120406

Recent progress on nanoparticles for targeted aneurysm treatment and imaging

Biomaterials. 2021 Jan:265:120406. doi: 10.1016/j.biomaterials.2020.120406. Epub 2020 Sep 21.

Authors

Nisakorn Yodsanit¹, Bowen Wang², Yi Zhao¹, Lian-Wang Guo³, K Craig Kent⁴, Shaoqin Gong⁵

Affiliations

¹ Department of Biomedical Engineering, And Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
² Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22903, USA.
³ Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22903, USA. Electronic address: LG8ZR@hscmail.mcc.virginia.edu.
⁴ Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22903, USA. Electronic address: CK8AQ@hscmail.mcc.virginia.edu.
⁵ Department of Biomedical Engineering, And Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Material Science and Engineering and Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53715, USA. Electronic address: shaoqingong@wisc.edu.

PMID: 32979792
DOI: 10.1016/j.biomaterials.2020.120406

Abstract

An abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta that plagues millions. Its rupture incurs high mortality rates (~80-90%), pressing an urgent need for therapeutic methods to prevent this deadly outcome. Judiciously designed nanoparticles (NPs) have displayed a unique potential to fulfill this need. Aneurysms feature excessive inflammation and extracellular matrix (ECM) degradation. As such, typically inflammatory cells and exposed ECM proteins have been targeted with NPs for therapeutic, diagnostic, or theranostic purposes in experimental models. NPs have been used not only for encapsulation and delivery of drugs and biomolecules in preclinical tests, but also for enhanced imaging to monitor aneurysm progression in patients. Moreover, they can be readily modified with various molecules to improve lesion targeting, detectability, biocompatibility, and circulation time. This review updates on the progress, limitations, and prospects of NP applications in the context of AAA.

Keywords: Abdominal aortic aneurysm; Imaging; Nanoparticles; Treatment.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Aorta, Abdominal
Aortic Aneurysm, Abdominal* / diagnostic imaging
Aortic Aneurysm, Abdominal* / drug therapy
Diagnostic Imaging
Disease Models, Animal
Humans
Nanoparticles*

Abstract

Publication types

MeSH terms

Grants and funding