Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters

Circ Res. 2020 Nov 6;127(11):1456-1458. doi: 10.1161/CIRCRESAHA.120.317686. Epub 2020 Sep 21.

Authors

Mengmeng Guo^#¹, Yitong Xu^#², Zhao Dong¹, Zihao Zhou¹, Nathan Cong¹, Mingming Gao², Wei Huang¹, Yuhui Wang¹, George Liu¹, Xunde Xian¹

Affiliations

¹ Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China (M.G., Z.D., Z.Z., N.C., W.H., Y.W., G.L., X.X.).
² Laboratory of Lipid Metabolism, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China (Y.X., M.G.).

^# Contributed equally.

PMID: 32951534
DOI: 10.1161/CIRCRESAHA.120.317686

No abstract available

Keywords: apolipoprotein; atherosclerosis; cardiovascular disease; lipoprotein lipase; mice.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apolipoprotein C-III / deficiency
Apolipoprotein C-III / genetics*
Atherosclerosis / genetics
Atherosclerosis / metabolism
Atherosclerosis / pathology
Atherosclerosis / prevention & control*
Biomarkers / blood
CRISPR-Associated Protein 9 / genetics*
CRISPR-Associated Protein 9 / metabolism
CRISPR-Cas Systems*
Clustered Regularly Interspaced Short Palindromic Repeats*
Diet, High-Fat
Disease Models, Animal
Gene Deletion*
Genetic Therapy*
Lipids / blood
Mesocricetus
Plaque, Atherosclerotic

Substances

Apolipoprotein C-III
Biomarkers
Lipids
CRISPR-Associated Protein 9