Effectiveness of antiresorptive medications in women on long-term dialysis after hip fracture: A population-based cohort study

PLoS One. 2020 Sep 2;15(9):e0238248. doi: 10.1371/journal.pone.0238248. eCollection 2020.

Abstract

There is no clear evidence how effective the antiresorptive (AR) drugs alendronate and raloxifene are at reducing risk of second hip fracture and mortality in dialysis populations. The purpose of this study was to compare the risk of hospitalization for second hip fracture and risk of mortality between AR user and non-user groups in Taiwanese women on long-term dialysis with hip fractures. We conducted a retrospective cohort study using Taiwan National Health Insurance Research Datasets. Long-term dialysis women older than 50 years with newly diagnosed hip fractures and new to AR therapy from 2005 to 2011 were recruited. The patients were divided into AR users and non-users and matched by propensity score. We used Cox Proportional Hazards models to assess association of AR with risks of second hip fracture and mortality. Totally, 1,079 dialysis patients were included, and after matching, we were left with 74 AR users and 74 non-users. AR users did not show a significant reduction in the incidence of second hip fracture compared with non-users (adjusted Hazard Ratio (HR): 0.91, 95% CI: 0.30-2.76), and alendronate users exhibited higher risk of second hip fracture compared with raloxifene users (adjusted HR: 2.80, 95% CI: 0.42-18.79). In addition, AR users were found to have significantly lower 1- and 2-year mortality rates than the non-users (1- year: adjusted HR 0.25, 95% CI, 0.07-0.90; 2-year: 0.35, 95%CI: 0.17-0.72). AR treatment did not significantly improve the risk of second hip fracture but significantly reduce mortality in older women on dialysis. Further clinical trials on effectiveness of AR medications for dialysis populations should be warranted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alendronate / administration & dosage*
  • Bone Density Conservation Agents / administration & dosage*
  • Female
  • Follow-Up Studies
  • Hip Fractures / epidemiology
  • Hip Fractures / mortality*
  • Hip Fractures / therapy
  • Humans
  • Incidence
  • Longitudinal Studies
  • Middle Aged
  • Prognosis
  • Raloxifene Hydrochloride / administration & dosage*
  • Renal Dialysis / mortality*
  • Retrospective Studies
  • Survival Rate
  • Taiwan / epidemiology

Substances

  • Bone Density Conservation Agents
  • Raloxifene Hydrochloride
  • Alendronate

Grants and funding

Any grants or fellowships supporting the writing of the paper: We would like to thank the Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan National Health Research Institutes, and Taiwan Ministry of Science and Technology for partly supporting this study. SJH is supported by Kaohsiung Medical University Hospital, Kaohsiung Medical University (grant number: KMUH104-4R09 and KMUH105-5R16), Taiwan National Health Research Institutes (grant number: NHRI-EX108-10505PI) and Taiwan Ministry of Science and Technology (grant number: MOST: 104-2314-B-037-073- MY3 and MOST: 107-2314-B-037-020-MY2). MYL is supported by Kaohsiung Medical University Hospital, Kaohsiung Medical University (grant number: KMUH105-5R17 and KMUH106-6R21), Taiwan Ministry of Science and Technology (grant number: MOST:105- 2314-B-037-065-, MOST: 106-2314-B-002-253-, MOST:107-2314-B-037-122- and MOST- 108-2314-B-037-110). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.