Multimodality imaging of COVID-19 pneumonia: from diagnosis to follow-up. A comprehensive review

Eur J Radiol. 2020 Oct:131:109217. doi: 10.1016/j.ejrad.2020.109217. Epub 2020 Aug 17.

Abstract

Due to its pandemic diffusion, SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection represents a global threat. Despite a multiorgan involvement has been described, pneumonia is the most common manifestation of COVID-19 (Coronavirus disease 2019) and it is associated with a high morbidity and a considerable mortality. Especially in the areas with high disease burden, chest imaging plays a crucial role to speed up the diagnostic process and to aid the patient management. The purpose of this comprehensive review is to understand the diagnostic capabilities and limitations of chest X-ray (CXR) and high-resolution computed tomography (HRCT) in defining the common imaging features of COVID-19 pneumonia and correlating them with the underlying pathogenic mechanisms. The evolution of lung abnormalities over time, the uncommon findings, the possible complications, and the main differential diagnosis occurring in the pandemic phase of SARS-CoV-2 infection are also discussed.

Keywords: COVID-19 pneumonia; Chest X-ray; Diagnosis; Differential diagnosis; Follow-up; High-resolution computed tomography.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / diagnostic imaging*
  • Diagnosis, Differential
  • Follow-Up Studies
  • Humans
  • Multimodal Imaging
  • Pandemics
  • Pneumonia, Viral / diagnostic imaging*
  • SARS-CoV-2
  • Tomography, X-Ray Computed / methods