Interaction of non-coding RNAs and Hippo signaling: Implications for tumorigenesis

Can Liu; Yangge Wu; Jian Ma

doi:10.1016/j.canlet.2020.08.012

Interaction of non-coding RNAs and Hippo signaling: Implications for tumorigenesis

Cancer Lett. 2020 Nov 28:493:207-216. doi: 10.1016/j.canlet.2020.08.012. Epub 2020 Aug 19.

Authors

Can Liu¹, Yangge Wu¹, Jian Ma²

Affiliations

¹ Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Cancer Research Institute, School of Basic Medical Science, NHC Key Laboratory of Carcinogenesis, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, China.
² Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Cancer Research Institute, School of Basic Medical Science, NHC Key Laboratory of Carcinogenesis, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: majian@csu.edu.cn.

PMID: 32822816
DOI: 10.1016/j.canlet.2020.08.012

Abstract

Hippo signaling is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis, and stem cell self-renewal by "turning off" or "turning on" the kinase cascade chain reaction to manipulate the expression of downstream genes. Dysregulation of the Hippo pathway contributes to cancer development and metastasis. Emerging evidence has revealed new insights into tumorigenesis through the interplay between the Hippo pathway and non-coding RNAs (ncRNAs), especially microRNA, long non-coding RNA and circular RNA. Here, we reviewed the interactions between the Hippo pathway and ncRNAs and their implication for a variety of tumor-promoting or tumor-repressing effects. These interactions have the potential to serve as cancer biomarkers and therapeutic targets in clinical applications.

Keywords: LATS1/2; MST1/2; YAP1; circRNA; lncRNA; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Proliferation
Gene Expression Regulation, Neoplastic
Hippo Signaling Pathway
Humans
Neoplasms / genetics
Neoplasms / pathology*
Protein Serine-Threonine Kinases / genetics
RNA, Untranslated / genetics*
Signal Transduction*

Substances

RNA, Untranslated
Protein Serine-Threonine Kinases