Biophysical signal transduction in cancer cells: Understanding its role in cancer pathogenesis and treatment

XiaoLei Huang; XiaoXu Yang; Chenchen Sun; ShuXia Huang; Min Cheng; Yangyang Han

doi:10.1016/j.bbcan.2020.188402

Biophysical signal transduction in cancer cells: Understanding its role in cancer pathogenesis and treatment

Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188402. doi: 10.1016/j.bbcan.2020.188402. Epub 2020 Aug 7.

Authors

XiaoLei Huang¹, XiaoXu Yang¹, Chenchen Sun¹, ShuXia Huang², Min Cheng³, Yangyang Han⁴

Affiliations

¹ School of Life Science and Technology, Weifang Medical University, Weifang, Shandong 261053, PR China.
² Department of Psychology, Weifang Medical University, Weifang, Shandong 261053, PR China.
³ Department of Physiology, Weifang Medical University, Weifang, Shandong 261053, PR China.
⁴ School of Life Science and Technology, Weifang Medical University, Weifang, Shandong 261053, PR China. Electronic address: hanyy@wfmc.edu.cn.

PMID: 32771535
DOI: 10.1016/j.bbcan.2020.188402

Abstract

Signaling between cells can promote both the development and progression of cancer. It has been found that chemical and physical signals, together with extracellular factors, can influence cancer progression. In this review, we focus on the physical microenvironment of cancer cells and examine the action of mechanical, electromagnetic, thermal, and acoustic signals on cancer cells, which may provide new directions for cancer research and treatment.

Keywords: Biophysical signals; Cancer progression; Cancer targets.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomechanical Phenomena
Disease Progression
Extracellular Matrix / physiology*
Humans
Neoplasms / metabolism
Neoplasms / pathology*
Signal Transduction
Thermodynamics
Tumor Microenvironment