Mol Cell Biol. 1988 Jan;8(1):124-9.

Complex translocation disrupts c-myc regulation in a human plasma cell myeloma.

Hollis GF, Gazdar AF, Bertness V, Kirsch IR.

Source

National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20814.

Abstract

A complex translocation has interrupted the third exon of the c-myc gene in human plasma cell myeloma tumor cells and a derivative cell line (NCI-H929). As a result of this rearrangement, a chimeric mRNA is expressed which commences 5' of the c-myc coding region and includes sequences introduced by the translocation event. All of the detectable c-myc-containing mRNA in the tumor and cell line was derived from this rearranged c-myc allele. This chimeric c-myc mRNA, in which most of the germ line c-myc 3' untranslated region has been replaced, was greater than sevenfold more stable than c-myc transcripts with intact 3' ends. This suggests that the 3' untranslated region may play an important role in c-myc mRNA stability.

PMID:: 3275865; [PubMed - indexed for MEDLINE]
PMCID:: PMC363091

Free PMC Article

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Secondary Source ID

GENBANK/M19724

LinkOut - more resources

Full Text Sources

Research Materials

ATCC CRL-9068 - American Type Culture Collection

Supplemental Content

Save items

Related citations in PubMed

Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas. [Oncogene. 1988]
Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas.
Julius MA, Street AJ, Fahrlander PD, Yang JQ, Eisenman RN, Marcu KB. Oncogene. 1988 May; 2(5):469-76.
A 3' truncation of MYC caused by chromosomal translocation in a human T-cell leukemia increases mRNA stability. [Oncogene. 1990]
A 3' truncation of MYC caused by chromosomal translocation in a human T-cell leukemia increases mRNA stability.
Aghib DF, Bishop JM, Ottolenghi S, Guerrasio A, Serra A, Saglio G. Oncogene. 1990 May; 5(5):707-11.
Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas. [Oncogene. 1989]
Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas.
Bauer SR, Piechaczyk M, Nordan RP, Owens JD, Nepveu A, Marcu KB, Mushinski JF. Oncogene. 1989 May; 4(5):615-23.
Review Oncogene activation by chromosomal rearrangement in chronic myelocytic leukemia. [Mutat Res. 1987]
Review Oncogene activation by chromosomal rearrangement in chronic myelocytic leukemia.
De Klein A. Mutat Res. 1987 Sep; 186(2):161-72.
Review The BCR/ABL hybrid gene. [Baillieres Clin Haematol. 1987]
Review The BCR/ABL hybrid gene.
Groffen J, Heisterkamp N. Baillieres Clin Haematol. 1987 Dec; 1(4):983-99.

See reviews... See all...

Cited by 11 PubMed Central articles

Review RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases. [Mol Med. 2010]
Review RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases.
Moraes KC. Mol Med. 2010 Jan-Feb; 16(1-2):53-68. Epub 2009 Oct 7.
Characterization of MYC translocations in multiple myeloma cell lines. [J Natl Cancer Inst Monogr. 2008]
Characterization of MYC translocations in multiple myeloma cell lines.
Dib A, Gabrea A, Glebov OK, Bergsagel PL, Kuehl WM. J Natl Cancer Inst Monogr. 2008; (39):25-31.
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. [Oncogene. 2008]
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Mazan-Mamczarz K, Hagner PR, Corl S, Srikantan S, Wood WH, Becker KG, Gorospe M, Keene JD, Levenson AS, Gartenhaus RB. Oncogene. 2008 Oct 16; 27(47):6151-63. Epub 2008 Jul 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Complex translocation disrupts c-myc regulation in a human plasma cell myeloma.
Complex translocation disrupts c-myc regulation in a human plasma cell myeloma.
Mol Cell Biol. 1988 Jan ;8(1):124-9.

PubMed
Role of temperature in regulation of spermatogenesis and the use of heating as a...
Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception.
Fertil Steril. 1988 Jan ;49(1):1-23.

PubMed
A bactericidal effect for human lactoferrin.
A bactericidal effect for human lactoferrin.
Science. 1977 Jul 15 ;197(4300):263-5.

PubMed
Quantitative basic residue requirements in the cleavage-activation site of the f...
Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus.
J Virol. 1988 Jan ;62(1):354-6.

PubMed
Characterization of complementary deoxyribonucleic acid for human adrenocortical...
Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency.
Mol Endocrinol. 1987 May ;1(5):348-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: