Science. 1977 Jul 15;197(4300):263-5.

A bactericidal effect for human lactoferrin.

Abstract

Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.

PMID:: 327545; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms. [Infect Immun. 1980]
Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms.
Arnold RR, Brewer M, Gauthier JJ. Infect Immun. 1980 Jun; 28(3):893-8.
Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation. [Infect Immun. 1982]
Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation.
Arnold RR, Russell JE, Champion WJ, Brewer M, Gauthier JJ. Infect Immun. 1982 Mar; 35(3):792-9.
Inhibition of mastitic bacteria by bovine milk apo-lactoferrin evaluated by in vitro microassay of bacterial growth. [J Dairy Sci. 1984]
Inhibition of mastitic bacteria by bovine milk apo-lactoferrin evaluated by in vitro microassay of bacterial growth.
Nonnecke BJ, Smith KL. J Dairy Sci. 1984 Mar; 67(3):606-13.
Review Lactoferrin and bacterial growth. [Nutr Rev. 1978]
Review Lactoferrin and bacterial growth.
. Nutr Rev. 1978 Jan; 36(1):22-3.
Review Lactoferrin functions: current status and perspectives. [J Clin Gastroenterol. 2004]
Review Lactoferrin functions: current status and perspectives.
Valenti P, Berlutti F, Conte MP, Longhi C, Seganti L. J Clin Gastroenterol. 2004 Jul; 38(6 Suppl):S127-9.

See reviews... See all...

Cited by 68 PubMed Central articles

Histochemical properties of sialic acids and antimicrobial substances in canine anal glands. [Eur J Histochem. 2011]
Histochemical properties of sialic acids and antimicrobial substances in canine anal glands.
Nara T, Yasui T, Fujimori O, Meyer W, Tsukise A. Eur J Histochem. 2011; 55(3):e29. Epub 2011 Aug 27.
Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin. [Infect Immun. 2011]
Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.
Mirza S, Wilson L, Benjamin WH Jr, Novak J, Barnes S, Hollingshead SK, Briles DE. Infect Immun. 2011 Jun; 79(6):2440-50. Epub 2011 Mar 21.
Antimicrobial mechanism of action of transferrins: selective inhibition of H+-ATPase. [Antimicrob Agents Chemother. 2...]
Antimicrobial mechanism of action of transferrins: selective inhibition of H+-ATPase.
Andrés MT, Fierro JF. Antimicrob Agents Chemother. 2010 Oct; 54(10):4335-42. Epub 2010 Jul 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A bactericidal effect for human lactoferrin.
A bactericidal effect for human lactoferrin.
Science. 1977 Jul 15 ;197(4300):263-5.

PubMed
Quantitative basic residue requirements in the cleavage-activation site of the f...
Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus.
J Virol. 1988 Jan ;62(1):354-6.

PubMed
Characterization of complementary deoxyribonucleic acid for human adrenocortical...
Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency.
Mol Endocrinol. 1987 May ;1(5):348-54.

PubMed
Occult biochemical pregnancy: fact or fiction?
Occult biochemical pregnancy: fact or fiction?
Br J Obstet Gynaecol. 1988 Jul ;95(7):659-63.

PubMed
Risk factors for spontaneous abortion and its recurrence.
Risk factors for spontaneous abortion and its recurrence.
Am J Epidemiol. 1988 Aug ;128(2):420-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A bactericidal effect for human lactoferrin.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 68 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information