J Virol. 1988 Jan;62(1):354-6.

Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus.

Glickman RL, Syddall RJ, Iorio RM, Sheehan JP, Bratt MA.

Source

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605.

Abstract

Newcastle disease virus exhibits a wide range of pathogenicity and virulence which, as with all paramyxoviruses, is directly related to the cleavability of a precursor (F0) of the fusion glycoprotein by cellular proteases. Sequence analyses of the cleavage site of several virulent and avirulent isolates of the Newcastle disease virus serotype reveal a correlation between virulence or pathogenicity and a high content of basic amino acid residues at the cleavage site. A similar correlation has been seen for other paramyxoviruses.

PMID:: 3275436; [PubMed - indexed for MEDLINE]
PMCID:: PMC250538

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus. [Virology. 1987]
Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus.
Toyoda T, Sakaguchi T, Imai K, Inocencio NM, Gotoh B, Hamaguchi M, Nagai Y. Virology. 1987 May; 158(1):242-7.
Comparison of the positions and efficiency of cleavage activation of fusion protein precursors of virulent and avirulent strains of Newcastle disease virus: insights into the specificities of activating proteases. [Virology. 1990]
Comparison of the positions and efficiency of cleavage activation of fusion protein precursors of virulent and avirulent strains of Newcastle disease virus: insights into the specificities of activating proteases.
Gorman JJ, Corino GL, Selleck PW. Virology. 1990 Jul; 177(1):339-51.
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases. [Microbiol Immunol. 1999]
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases.
Fujii Y, Sakaguchi T, Kiyotani K, Yoshida T. Microbiol Immunol. 1999; 43(2):133-40.
Review The structure and function of paramyxovirus glycoproteins. [Med Microbiol Immunol. 1977]
Review The structure and function of paramyxovirus glycoproteins.
Klenk HD, Nagai Y, Rott R, Nicolau C. Med Microbiol Immunol. 1977; 164(1-3):35-47.
Review [A molecular basis for the variations in virulence of Newcastle disease virus (author's transl)]. [Tanpakushitsu Kakusan Koso. 1977]
Review [A molecular basis for the variations in virulence of Newcastle disease virus (author's transl)].
Nagai Y. Tanpakushitsu Kakusan Koso. 1977 May; 22(5):385-95.

See reviews... See all...

Cited by 32 PubMed Central articles

Virulence of newcastle disease virus: what is known so far? [Vet Res. 2011]
Virulence of newcastle disease virus: what is known so far?
Dortmans JC, Koch G, Rottier PJ, Peeters BP. Vet Res. 2011 Dec 23; 42(1):122. Epub 2011 Dec 23.
Genotypic and pathotypic characterization of Newcastle disease viruses from India. [PLoS One. 2011]
Genotypic and pathotypic characterization of Newcastle disease viruses from India.
Tirumurugaan KG, Kapgate S, Vinupriya MK, Vijayarani K, Kumanan K, Elankumaran S. PLoS One. 2011; 6(12):e28414. Epub 2011 Dec 9.
The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties. [Virus Res. 2010]
The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.
Alamares JG, Elankumaran S, Samal SK, Iorio RM. Virus Res. 2010 Jan; 147(1):153-7. Epub 2009 Nov 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Quantitative basic residue requirements in the cleavage-activation site of the f...
Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus.
J Virol. 1988 Jan ;62(1):354-6.

PubMed
Characterization of complementary deoxyribonucleic acid for human adrenocortical...
Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency.
Mol Endocrinol. 1987 May ;1(5):348-54.

PubMed
Occult biochemical pregnancy: fact or fiction?
Occult biochemical pregnancy: fact or fiction?
Br J Obstet Gynaecol. 1988 Jul ;95(7):659-63.

PubMed
Risk factors for spontaneous abortion and its recurrence.
Risk factors for spontaneous abortion and its recurrence.
Am J Epidemiol. 1988 Aug ;128(2):420-30.

PubMed
Effect of injection site on circulation times during cardiac arrest.
Effect of injection site on circulation times during cardiac arrest.
Crit Care Med. 1988 Nov ;16(11):1138-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: