Acute Gouty Arthritis During Favipiravir Treatment for Coronavirus Disease 2019

Intern Med. 2020 Sep 15;59(18):2327-2329. doi: 10.2169/internalmedicine.5377-20. Epub 2020 Jul 28.

Abstract

A 42-year-old man exhibiting hypoxia was diagnosed with coronavirus disease 2019. He had medical histories of type 2 diabetes, hyperlipidemia, hyperuricemia, and gout attack. He received favipiravir for compassionate use for 14 days. Subsequently, he showed increased uric acid levels and developed acute gouty arthritis. Favipiravir may induce not only hyperuricemia but also acute gouty arthritis. It should therefore be used with caution in patients with a history of gout and those with hyperuricemia, especially when used at a higher dose and for a longer duration than is typical.

Keywords: acute gouty arthritis; coronavirus disease 2019 (COVID-19); favipiravir; hyperuricemia; severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amides / adverse effects*
  • Amides / therapeutic use
  • Antiviral Agents / adverse effects*
  • Antiviral Agents / therapeutic use
  • Arthritis, Gouty / chemically induced*
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / complications
  • Coronavirus Infections / drug therapy*
  • Humans
  • Hyperuricemia / complications
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / drug therapy*
  • Pyrazines / adverse effects*
  • Pyrazines / therapeutic use
  • SARS-CoV-2
  • Uric Acid / urine

Substances

  • Amides
  • Antiviral Agents
  • Pyrazines
  • Uric Acid
  • favipiravir