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    Neuron. 1988 Apr;1(2):127-32.

    Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.

    Source

    Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts 02115.

    Abstract

    The growth-associated protein (GAP-43) is considered a crucial component of an effective regenerative response in the nervous system. Its phosphorylation by protein kinase C correlates with long-term potentiation. Sequence analysis of human cDNAs coding for this protein shows that the human GAP-43 gene is highly homologous to the rat gene; this homology extends into the 3'-untranslated region. However, the human protein contains a 10 amino acid insert. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16.

    PMID:
    3272162
    [PubMed - indexed for MEDLINE]

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