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    Drugs Exp Clin Res. 1988;14(5):319-25.

    Comparative study on effects of 14- and 16-membered macrolides on gastrointestinal motility in unanaesthetized dogs.

    Nakayoshi T, Izumi M, Shinkai S, Fujita M.

    Source

    Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Kawasaki, Japan.

    Abstract

    Comparative studies on the effects of 14-membered and 16-membered macrolides on gastrointestinal motility were conducted in unanaesthetized dogs. Midecamycin acetate, a new 16-membered macrolide, and leucomycin, another 16-membered macrolide, did not disturb the gastrointestinal motility and no dogs showed any adverse effects. In contrast, erythromycin stearate, erythromycin ethylsuccinate and triacetyloleandomycin, 14-membered macrolides, caused adverse effects such as strong contractile motility, nausea, vomiting and diarrhoea. The adverse effects of macrolides on the gastrointestinal tract are related to their chemical structure.

    PMID:
    3265375
    [PubMed - indexed for MEDLINE]

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