Microbiome: Emerging Concepts in Patients with Chronic Liver Disease

Clin Liver Dis. 2020 Aug;24(3):493-520. doi: 10.1016/j.cld.2020.04.006. Epub 2020 May 24.

Abstract

The gut microbiome is an exciting new area of research in chronic liver disease. It has shown promise in expanding our understanding of these complicated disease processes and has opened up new treatment modalities. The aim of this review is to increase understanding of the microbiome and explain the collection and analysis process in the context of liver disease. It also looks at our current understanding of the role of the microbiome in the wide spectrum of chronic liver diseases and how it is being used in current therapies and treatments.

Keywords: Cirrhosis; Fecal transplant; Hepatic encephalopathy; Outcomes.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Carcinoma, Hepatocellular / microbiology
  • Chronic Disease
  • Dysbiosis / complications*
  • Dysbiosis / therapy*
  • Fecal Microbiota Transplantation
  • Gastrointestinal Microbiome* / drug effects
  • Hepatic Encephalopathy / microbiology
  • Humans
  • Liver Cirrhosis / complications
  • Liver Diseases / complications
  • Liver Diseases / microbiology*
  • Liver Neoplasms / microbiology
  • Prebiotics

Substances

  • Anti-Bacterial Agents
  • Prebiotics