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Nature. 1988 Jun 23;333(6175):742-6.

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.

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  • 1Basel Institute for Immunology, Switzerland.


The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.

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