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Nature. 1988 Jun 9;333(6173):571-3.

Stimulation of B-cell progenitors by cloned murine interleukin-7.

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  • 1Immunex Corporation, Seattle, Washington 98101.


The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.

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