Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Eur J Clin Invest. 2020 Nov;50(11):e13320. doi: 10.1111/eci.13320. Epub 2020 Jul 13.

Abstract

Background: There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases.

Aim: To evaluate the degree of OS in people with morbid obesity and its relationship with glycoproteins, determined using 1H-NMR spectroscopy, before and after bariatric surgery (BS).

Methods: In this observational cohort study, plasma from 24 patients with BMI ≥ 40 kg/m2 (age: 21-65 years) was used to measure metabolites implicated in OS. We measured glycoprotein (GlycA, GlycB and GlycF) areas and shape factors (H/W = height/width).

Results: One year after BS, oxidized low-density lipoprotein had decreased by 49% (P < .0001), malondialdehyde by 32% (P = .0019) and lipoprotein (a) by 21% (P = .0039). The antioxidant enzymes paraoxonase-1 and catalase increased after BS (43%, P < .0001 and 54%, P = .0002, respectively). Superoxide dismutase-2 had fallen 1 year after BS (32%, P = .0052). After BS, both the glycoprotein areas and shape factors decreased by 20%-26%. These glycoproteins were significantly correlated with OS parameters. The plasma atherogenic index was 63% higher in obese individuals than 1 year after BS and correlated positively with glycoproteins.

Conclusion: For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.

Keywords: 1H-NMR; atherosclerosis; bariatric surgery; glycoproteins; morbid obesity; oxidative stress.

Publication types

  • Observational Study

MeSH terms

  • Acetylgalactosamine / blood
  • Acetylglucosamine / blood
  • Adult
  • Aged
  • Aryldialkylphosphatase / blood
  • Bariatric Surgery
  • Catalase / blood
  • Cohort Studies
  • Female
  • Glycoproteins / blood*
  • Glycosylation
  • Humans
  • Lipoprotein(a) / blood
  • Lipoproteins, LDL / blood
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • N-Acetylneuraminic Acid / blood
  • Obesity, Morbid / blood
  • Obesity, Morbid / surgery*
  • Oxidative Stress*
  • Proton Magnetic Resonance Spectroscopy
  • Superoxide Dismutase / blood
  • Treatment Outcome
  • Young Adult

Substances

  • Glycoproteins
  • Lipoprotein(a)
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • Malondialdehyde
  • Catalase
  • Superoxide Dismutase
  • superoxide dismutase 2
  • Aryldialkylphosphatase
  • PON1 protein, human
  • N-Acetylneuraminic Acid
  • Acetylgalactosamine
  • Acetylglucosamine