J Hypertens Suppl. 1988 Dec;6(4):S529-31.

Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?

Hedner J, Ejnell H, Sellgren J, Hedner T, Wallin G.

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Department of Clinical Pharmacology, Sahlgren's University Hospital, Gothenburg, Sweden.

Abstract

Muscle nerve sympathetic activity was recorded in six patients with the sleep apnoea syndrome (SAS). Compared with age- and sex-matched control patients, an increased activity during wakefulness was found. Sleep apnoic events were associated with sequencies of progressively increasing sympathetic activity followed by a sudden reduction of activity. The high sympathetic activity associated with SAS may be important in the development of the systemic hypertension commonly seen in these patients.

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