Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application

Siyu Wang; Fei Yan; Ping Ren; Yi Li; Qiong Wu; Xuedong Fang; Fangfang Chen; Ce Wang

doi:10.1016/j.ijbiomac.2020.04.116

Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application

Int J Biol Macromol. 2020 Apr 27:158:9-17. doi: 10.1016/j.ijbiomac.2020.04.116. Online ahead of print.

Authors

Siyu Wang¹, Fei Yan², Ping Ren³, Yi Li², Qiong Wu¹, Xuedong Fang¹, Fangfang Chen⁴, Ce Wang⁵

Affiliations

¹ Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, PR China.
² State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, PR China.
³ Key Laboratory of Zoonoses Research, Ministry of Education, Jilin University, Changchun 130012, PR China; Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, PR China.
⁴ Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, PR China; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, PR China; Key Laboratory of Zoonoses Research, Ministry of Education, Jilin University, Changchun 130012, PR China. Electronic address: cff@jlu.edu.cn.
⁵ Alan G. Macdiarmid Institute, College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China. Electronic address: cwang@jlu.edu.cn.

PMID: 32353508
DOI: 10.1016/j.ijbiomac.2020.04.116

Abstract

Developing wound dressing that inhibits bacterial infection for treating complex wound healing processes has been a research hotspot. Here, we report the fabrication of Cu-MOFs (HKUST-1) incorporated electrospun chitosan/polyvinyl alcohol (HKUST-1/chitosan/PVA) fibers through the blending electrospinning for wound therapy. HKUST-1/chitosan/PVA fibers displayed satisfying physical properties, such as mechanical property, water uptake, water vapor transmission rate, etc. Cytotoxicity test indicated that HKUST-1/chitosan/PVA fibers were biocompatible and could support cell adhesion. Due to the HKUST-1 incorporation, HKUST-1/chitosan/PVA fibers exhibited the good antibacterial activity against Escherichia coli and Staphylococcus aureus with 99% antibacterial efficiency. Furthermore, in animal studies, compared with commercial chitosan dressings and chitosan/PVA fibers, HKUST-1/chitosan/PVA fibers were more efficient to heal the wound with less inflammation. In summary, the HKUST-1/chitosan/PVA fibers with good physicochemical property, biocompatibility and antibacterial property is an excellent wound dressing for full-thickness skin repair.

Keywords: Chitosan; Electrospinning; Metal-organic framework; Wound dressing.