Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection

Eur Respir J. 2020 Jun 4;55(6):2001023. doi: 10.1183/13993003.01023-2020. Print 2020 Jun.

Abstract

Circadian deregulation and poor or insufficient sleep may facilitate COVID-19 infection and severity https://bit.ly/2VUlIIJ

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • ARNTL Transcription Factors / genetics
  • Adaptive Immunity / immunology*
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus / metabolism
  • Betacoronavirus / pathogenicity
  • Betacoronavirus / physiology*
  • COVID-19
  • Circadian Clocks / genetics
  • Circadian Clocks / immunology*
  • Coronavirus Infections / immunology*
  • Herpesviridae Infections / genetics
  • Humans
  • Immunity, Innate / immunology*
  • Jet Lag Syndrome
  • Mice
  • Pandemics
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / immunology*
  • SARS-CoV-2
  • Seasons
  • Shift Work Schedule
  • Sleep Apnea, Obstructive
  • Sleep Deprivation / immunology*
  • Spike Glycoprotein, Coronavirus / metabolism
  • Virus Replication*

Substances

  • ARNTL Transcription Factors
  • Bmal1 protein, mouse
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Ace2 protein, mouse
  • Angiotensin-Converting Enzyme 2