Send to:

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 1988 Dec;15(12):1827-32.

The role of metabolic factors and blood pressure in the association of obesity with osteoarthritis of the knee.

Author information

  • 1Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco 94143-0560.


The role of systemic/metabolic factors in the association of obesity with knee osteoarthritis (OA) was analyzed using radiographic data, metabolic measures, and blood pressure for 3885 American adults aged 45-74 from the U.S. National Health and Nutrition Examination Survey, 1971-1975 (NHANES I). Obesity was associated with both bilateral and unilateral OA, but more strongly with bilateral OA. Controlling for age, sex, serum cholesterol, serum uric acid, diabetes, body fat distribution, and blood pressure did not significantly reduce the association between obesity and knee OA. Findings from these data are not supportive of a metabolic link between obesity and knee OA.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk