Management of viral hepatitis A, C, D and E in pregnancy

Best Pract Res Clin Obstet Gynaecol. 2020 Oct:68:44-53. doi: 10.1016/j.bpobgyn.2020.03.009. Epub 2020 Mar 21.

Abstract

Viral hepatitis can cause significant maternal and neonatal morbidity and mortality. Hepatitis A and E mainly present as acute hepatitis during pregnancy, while hepatitis C and D are usually found as chronic infection in pregnant women. Hepatitis A remains self-limiting during pregnancy while hepatitis E has a higher prevalence and manifests with a rigorous course in pregnant women. Screening of hepatitis C during pregnancy and its subsequent management during pregnancy are still a debatable topic. New treatments of hepatitis C and E require further evaluation for use in pregnancy. This review summarizes the prevalence, clinical manifestations, maternal, foetal and neonatal effects, and the management of hepatitis A, C, D and E viral infection during pregnancy.

Keywords: Hepatitis A; Hepatitis C; Hepatitis D; Hepatitis E; Pregnancy; Vaccination.

Publication types

  • Review

MeSH terms

  • Female
  • Hepatitis A / diagnosis
  • Hepatitis A / epidemiology
  • Hepatitis A / therapy*
  • Hepatitis C / diagnosis
  • Hepatitis C / epidemiology
  • Hepatitis C / therapy*
  • Hepatitis D / diagnosis
  • Hepatitis D / epidemiology
  • Hepatitis D / therapy*
  • Hepatitis E / diagnosis
  • Hepatitis E / epidemiology
  • Hepatitis E / therapy*
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Complications, Infectious / epidemiology
  • Pregnancy Complications, Infectious / therapy
  • Pregnancy Complications, Infectious / virology*
  • Prenatal Care
  • Prevalence