Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Bin Zhang; Shuyi Liu; Tan Tan; Wenhui Huang; Yuhao Dong; Luyan Chen; Qiuying Chen; Lu Zhang; Qingyang Zhong; Xiaoping Zhang; Yujian Zou; Shuixing Zhang

doi:10.1016/j.chest.2020.03.039

Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Chest. 2020 Jul;158(1):e9-e13. doi: 10.1016/j.chest.2020.03.039. Epub 2020 Mar 31.

Authors

Bin Zhang¹, Shuyi Liu¹, Tan Tan², Wenhui Huang¹, Yuhao Dong³, Luyan Chen¹, Qiuying Chen¹, Lu Zhang¹, Qingyang Zhong⁴, Xiaoping Zhang⁵, Yujian Zou⁶, Shuixing Zhang⁷

Affiliations

¹ The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong.
² The Xiangtan Central Hospital, Xiangtan, Hunan.
³ Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong.
⁴ Dongguan Ninth People's Hospital, Dongguan, Guangdong.
⁵ The Second People's Hospital of Zhongshan, Zhongshan, Guangdong.
⁶ Dongguan People's Hospital, Dongguan, Guangdong, China.
⁷ The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong. Electronic address: shui7515@126.com.

Abstract

As of March 24, 2020, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for 379,661 infection cases with 16,428 deaths globally, and the number is still increasing rapidly. Herein, we present four critically ill patients with SARS-CoV-2 infection who received supportive care and convalescent plasma. Although all four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy.

Keywords: SARS-CoV-2; convalescent plasma; critical illness.

Publication types

Case Reports

MeSH terms

Adult
Aged
Antifungal Agents / administration & dosage
Antiviral Agents* / administration & dosage
Antiviral Agents* / classification
Betacoronavirus / isolation & purification
COVID-19
COVID-19 Serotherapy
COVID-19 Testing
Clinical Laboratory Techniques / methods
Coronavirus Infections* / complications
Coronavirus Infections* / diagnosis
Coronavirus Infections* / physiopathology
Coronavirus Infections* / therapy
Critical Illness / therapy*
Extracorporeal Membrane Oxygenation / methods
Female
Humans
Immunization, Passive / methods
Male
Middle Aged
Pandemics*
Pneumonia, Viral* / complications
Pneumonia, Viral* / diagnosis
Pneumonia, Viral* / microbiology
Pneumonia, Viral* / physiopathology
Pneumonia, Viral* / therapy
Pregnancy
Pregnancy Complications, Infectious* / physiopathology
Pregnancy Complications, Infectious* / therapy
Pregnancy Complications, Infectious* / virology
Radiography, Thoracic / methods
Respiration, Artificial / methods
SARS-CoV-2
Tomography, X-Ray Computed / methods
Treatment Outcome

Substances

Antifungal Agents
Antiviral Agents