Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19

Mulong Du; Guoshuai Cai; Feng Chen; David C Christiani; Zhengdong Zhang; Meilin Wang

doi:10.1053/j.gastro.2020.03.045

Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19

Gastroenterology. 2020 Jun;158(8):2298-2301.e7. doi: 10.1053/j.gastro.2020.03.045. Epub 2020 Mar 28.

Authors

Mulong Du¹, Guoshuai Cai², Feng Chen³, David C Christiani⁴, Zhengdong Zhang⁵, Meilin Wang⁶

Affiliations

¹ Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China; Departments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
² Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
³ Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China.
⁴ Departments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
⁵ Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: drzdzhang@njmu.edu.cn.
⁶ Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: mwang@njmu.edu.cn.

No abstract available

Keywords: COVID-19; Gastrointestinal Symptoms; Multiomics; SARS-CoV-2.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Angiotensin-Converting Enzyme 2
Betacoronavirus / isolation & purification
Betacoronavirus / pathogenicity*
COVID-19
China / epidemiology
Coronavirus Infections / genetics
Coronavirus Infections / pathology
Coronavirus Infections / transmission*
Coronavirus Infections / virology
Datasets as Topic
Feces / virology
Female
Gastrointestinal Diseases / diagnosis
Gastrointestinal Diseases / genetics
Gastrointestinal Diseases / pathology*
Gastrointestinal Diseases / virology
Gene Expression Profiling / methods
Genetic Association Studies
Genetic Predisposition to Disease
Genomics / methods
Humans
Intestinal Mucosa / pathology
Intestinal Mucosa / virology
Male
Middle Aged
Pandemics
Peptidyl-Dipeptidase A / genetics
Peptidyl-Dipeptidase A / metabolism*
Phenotype
Pneumonia, Viral / genetics
Pneumonia, Viral / pathology
Pneumonia, Viral / transmission*
Pneumonia, Viral / virology
Polymorphism, Single Nucleotide
Proteomics / methods
SARS-CoV-2
Signal Transduction / genetics
Single-Cell Analysis / methods
Young Adult

Substances

Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2