Interactions among endotoxin, uric acid, and lactate in relation to the risk of type 2 diabetes: A population-based study

J Diabetes. 2020 Aug;12(8):605-615. doi: 10.1111/1753-0407.13039. Epub 2020 Apr 20.

Abstract
in English, Chinese

Background: Blood levels of endotoxin, uric acid (UA), or lactate (LAC) are associated with type 2 diabetes mellitus (T2DM). Thus, we explored the interactions among blood endotoxin, UA, and LAC levels and the risk of T2DM.

Methods: This population-based cross-sectional study included 2520 Chinese adults. Fasting blood endotoxin, UA, and LAC levels were determined and the cut-off values were obtained from the receiver operating characteristic curve analysis. The study population was classified into two or four subgroups based on low or high, or both low and high levels of endotoxin, UA, and LAC, respectively.

Results: The odds ratios (ORs) for T2DM (all P < .05) were higher in the high groups than the low groups of endotoxin, UA, or LAC, respectively. Participants in the groups with high levels of both endotoxin and UA, endotoxin and LAC, or UA and LAC, had 4.71 (95% CI 3.01-7.37), 5.13 (95% CI 3.29-7.99), or 3.73 (95% CI 2.34-5.94) times higher risk for T2DM compared to those in groups with low levels of both endotoxin and UA, endotoxin and LAC, or UA and LAC (all P < 0.05), respectively. In the interaction analysis, an interactive effect between endotoxin and UA (P < .05), or endotoxin and LAC (P < .05), but not UA and LAC, was observed that contributed to an increased risk of T2DM.

Conclusions: The interaction between levels of endotoxin and UA or levels of endotoxin and LAC was related to an increased risk of T2DM in the Chinese population.

背景: 血内毒素、尿酸(UA)或乳酸(LAC)水平与2型糖尿病(T2DM)密切相关。因此, 我们探讨了血内毒素、UA和LAC水平之间的相互作用与T2DM患病风险的关系。 方法: 这项基于人群的横断面研究包括2520名中国成年人。我们检测了参与者空腹血内毒素、UA和LAC水平, 并通过受试者工作特征曲线(ROC)分析获得各个指标的切点。根据血内毒素、UA和LAC的低或高水平, 或联合的低和高水平, 分别将研究人群分为两组或四组。 结果: 在高内毒素、高UA或高LAC水平组, 2型糖尿病的优势比(OR)分别高于低内毒素、低UA或低LAC水平组(P均<0.05)。在高内毒素与高UA水平组、高内毒素与高LAC水平组、高UA与高LAC水平组, T2DM的患病风险分别是低内毒素与低UA水平组、低内毒素与低LAC水平组、低UA与低LAC水平组的4.71倍(95%CI 3.01~7.37)、5.13倍(95%CI 3.29~7.99)、3.73倍(95%CI 2.34~5.94)(P均<0.05)。在交互作用分析中, 内毒素与UA(P<0.05)或内毒素与LAC(P<0.05)之间的交互作用, 而不是UA与LAC之间的交互作用增高了T2DM的患病风险。 结论: 在中国人群中, 内毒素与UA水平或内毒素与LAC水平之间的相互作用与T2DM的患病风险增高密切相关。.

Keywords: 2型糖尿病(T2DM); endotoxin; lactate (LAC); type 2 diabetes mellitus (T2DM); uric acid (UA); 乳酸(LAC); 内毒素; 尿酸(UA).

MeSH terms

  • Adult
  • Aged
  • China / epidemiology
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / etiology*
  • Endotoxins / blood*
  • Female
  • Humans
  • Lactic Acid / blood*
  • Male
  • Middle Aged
  • Risk Factors
  • Sensitivity and Specificity
  • Uric Acid / blood*

Substances

  • Endotoxins
  • Uric Acid
  • Lactic Acid