Genomics. 1988 Jul;3(1):87-90.

Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1.

Henry I, Bernheim A, Bernard M, van der Rest M, Kimura T, Jeanpierre C, Barichard F, Berger R, Olsen BR, Ramirez F, et al.

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INSERM U73, Genetique et Pathologie Foetale, Paris, France.

Abstract

Type XI collagen is a minor and poorly characterized structural component of cartilage. Recently, cDNA and genomic clones coding for the pro alpha 1 chain of human Type XI collagen, formerly 1 alpha collagen, have been isolated and fully characterized. Here we have used one such probe to establish the chromosomal localization of the pro alpha 1 (XI) collagen gene (COL11A1) by hybridization to filter-bound DNA isolated from flow-sorted chromosomes and by in situ hybridization on metaphase chromosomes. This combination of approaches has enabled us to locate COL1A11 in the p21 region of chromosome 1. This represents the first mapping of a Type XI collagen gene and the first assignment of a collagen locus to chromosome 1. These studies also provide additional evidence for the nearly uniform dispersion of the human fibrillar collagen genes in the human genome.

PMID:: 3220479; [PubMed - indexed for MEDLINE]

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The human alpha 2(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization. [J Biol Chem. 1989]
The human alpha 2(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization.
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Cited by 4 PubMed Central articles

Marshall syndrome associated with a splicing defect at the COL11A1 locus. [Am J Hum Genet. 1998]
Marshall syndrome associated with a splicing defect at the COL11A1 locus.
Griffith AJ, Sprunger LK, Sirko-Osadsa DA, Tiller GE, Meisler MH, Warman ML. Am J Hum Genet. 1998 Apr; 62(4):816-23.
Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene. [Am J Hum Genet. 1994]
Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene.
Briggs MD, Choi H, Warman ML, Loughlin JA, Wordsworth P, Sykes BC, Irven CM, Smith M, Wynne-Davies R, Lipson MH. Am J Hum Genet. 1994 Oct; 55(4):678-84.
Molecular cloning of alpha 5(IV) collagen and assignment of the gene to the region of the X chromosome containing the Alport syndrome locus. [Am J Hum Genet. 1990]
Molecular cloning of alpha 5(IV) collagen and assignment of the gene to the region of the X chromosome containing the Alport syndrome locus.
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Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p...
Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1.
Genomics. 1988 Jul ;3(1):87-90.

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