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1: Genomics. 1988 Jul;3(1):48-52.Click here to read Links

The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11.

Law ML, Cai GY, Hartz JA, Jones C, Kao FT.

Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206.

Using human hemopexin cDNA clones isolated from lambda gt11 cDNA library as probes, we have carried out Southern blot analysis of a series of human-Chinese hamster somatic cell hybrids containing different combinations of human chromosomes. Synteny analysis revealed 100% concordance between the hemopexin gene and human chromosome 11. In situ hybridization of 3H-labeled hemopexin cDNA to metaphase chromosomes prepared from human lymphocytes further localized the gene to the region p15.4-p15.5, the same location as the beta-globin gene cluster.

PMID: 3220477 [PubMed - indexed for MEDLINE]