Tip of the iceberg: roles of circRNAs in hematological malignancies

Shan-Shan Guo; Bi-Xia Li; Duo-Bing Zou; Shu-Jun Yang; Li-Xia Sheng; Gui-Fang Ouyang; Qi-Tian Mu; He Huang

Tip of the iceberg: roles of circRNAs in hematological malignancies

Am J Cancer Res. 2020 Feb 1;10(2):367-382. eCollection 2020.

Authors

Shan-Shan Guo¹, Bi-Xia Li², Duo-Bing Zou³, Shu-Jun Yang^{3

4}, Li-Xia Sheng⁴, Gui-Fang Ouyang⁴, Qi-Tian Mu³, He Huang⁵

Affiliations

¹ Ningbo Hospital, School of Medicine, Zhejiang University Ningbo, Zhejiang, PR China.
² Ningbo University School of Medicine Ningbo, Zhejiang, PR China.
³ Laboratory of Stem Cell Transplantation, Ningbo Hospital, School of Medicine, Zhejiang University Ningbo, Zhejiang, PR China.
⁴ Department of Hematology, Ningbo Hospital, School of Medicine, Zhejiang University Ningbo, Zhejiang, PR China.
⁵ Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang, PR China.

PMID: 32195014
PMCID: PMC7061755

Abstract

Circular RNAs (circRNAs) are a new class of covalently closed RNA molecules whose 3'- and 5'-ends are linked by a back-splicing event. Emerging evidence has shown that circRNAs play a vital role in the occurrence and development of many diseases and are promising biomarkers and therapeutic targets. However, knowledge of circRNAs in hematological malignancies is limited. In this review, the biogenesis, categories, characteristics, and functions of circRNAs are summarized, especially the roles of circRNAs in hematopoiesis and hematological malignancies.

Keywords: acute myeloid leukemia; chronic myeloid leukemia; circRNA; hematopoiesis; lymphoid malignancies.

Publication types

Review