Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects

Jing Wang; Jin Zhang; Kai Liu; Jinfeng He; Yongqiang Zhang; Shengfu Chen; Guanglong Ma; Yanshuai Cui; Longgang Wang; Dawei Gao

doi:10.1016/j.ijpharm.2020.119231

Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects

Int J Pharm. 2020 Apr 30:580:119231. doi: 10.1016/j.ijpharm.2020.119231. Epub 2020 Mar 16.

Authors

Jing Wang¹, Jin Zhang², Kai Liu³, Jinfeng He³, Yongqiang Zhang³, Shengfu Chen⁴, Guanglong Ma⁴, Yanshuai Cui⁵, Longgang Wang⁶, Dawei Gao⁷

Affiliations

¹ State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China.
² College of Chemistry and Environmental Engineering, Shanxi Datong University, Datong 037009, China.
³ Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China.
⁴ Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
⁵ State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China. Electronic address: cuiyanshuai09@163.com.
⁶ State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China; Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China. Electronic address: lgwang@ysu.edu.cn.
⁷ State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China; Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China. Electronic address: dwgao@ysu.edu.cn.

PMID: 32194207
DOI: 10.1016/j.ijpharm.2020.119231

Abstract

The development of effective agents for cancer therapy and inhibition of bacterial infection has drawn a great deal of interest. Photothermal therapy has been widely used for the thermal ablation of tumor cells. In addition, antibiotics have the ability to inhibit the growth of bacteria. Thus, the combination of photothermal therapy and antibiotics may be one of the methods to address the problem. Herein, it is the first time that daptomycin (Dap) micelles were used as the template and reducing agents to prepare stable daptomycin-gold nanoflowers (Dap-Au_nNFs) under mild conditions. The energy dispersive spectrometer (EDS) spectrum and X-ray diffraction (XRD) spectrum indicated that Dap-Au_nNFs were successfully prepared. When the molar ratio of HAuCl₄ to Dap was 6, the gold nanoparticles inside of Dap-Au_nNFs were about 80 nm with flower-like shape. In addition, the photothermal conversion efficiency of Dap-Au₆NFs was about 40%. More importantly, Dap-Au₆NFs inhibited the growth of tumors and bacteria under the radiation of near-infrared light at 808 nm. The prepared Dap-Au₆NFs could be used as photothermal antitumor and antibacterial agents in the future.

Keywords: Antibacterial; Antitumor; Biomineralization; Daptomycin; Gold nanoflower; Photothermal.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Daptomycin / chemistry*
Daptomycin / pharmacology*
Female
Gold / chemistry*
Metal Nanoparticles / chemistry*
Mice
Micelles
Neoplasms / drug therapy
Phototherapy / methods

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Micelles
Gold
Daptomycin