Oxidative Stress in Hemodialysis Pediatric Patients

Mohamed G Shouman; Samar Sabry; Rasha E E Galal; Emad Salama; Aliaa Ahmed Wahby; Eman Awadallah; Abeer Selim

doi:10.3889/oamjms.2019.859

Oxidative Stress in Hemodialysis Pediatric Patients

Open Access Maced J Med Sci. 2019 Dec 10;7(23):3955-3959. doi: 10.3889/oamjms.2019.859. eCollection 2019 Dec 15.

Authors

Mohamed G Shouman¹, Samar Sabry², Rasha E E Galal², Emad Salama¹, Aliaa Ahmed Wahby³, Eman Awadallah³, Abeer Selim¹

Affiliations

¹ Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.
² Pediatrics Department, Pediatric Nephrology Unit, Cairo University, Cairo, Egypt.
³ Clinical Pathology Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Abstract

Background: Oxidative stress may play a role in complications of hemodialysis patients as atherosclerosis, thrombosis, and inflammation.

Aim: The aim of the study was to evaluate the oxidative stress in hemodialysis pediatric patients through measurement of oxidative stress enzymes as paraoxanase activity (PON), arylesterase activity (ASA), superoxide dismutase (SOD) and also non-enzymatic antioxidant vitamins as vitamins A, C and E levels.

Methods: The study included 50 hemodialysis pediatric patients with mean age 11.4 ± 5.4 years and 30 normal children of matched sex and age as a control group. Assessment of oxidative stresses was done using ELIZA technique.

Results: SOD, ASA, and vitamin C were significantly lower among hemodialysis patients in comparison to control group (p = 0.004, 0.004, > 0.001 respectively).

Conclusion: The study concluded that oxidative stress was common finding in hemodialysis pediatric patients which may play a role in complications encountered among these patients.

Keywords: Antioxidants; Arylesterase; C; E; Hemodialysis; Paraoxinase; Pediatric; Superoxide dismutase; Vitamins A.