Neonatal Autoimmune Lymphoproliferative Syndrome: A Case Report and A Brief Review

Jayasree Chandramati; Neeraj Sidharthan; Sasidharan Ponthenkandath

doi:10.1097/MPH.0000000000001777

Neonatal Autoimmune Lymphoproliferative Syndrome: A Case Report and A Brief Review

J Pediatr Hematol Oncol. 2021 Mar 1;43(2):e227-e229. doi: 10.1097/MPH.0000000000001777.

Authors

Jayasree Chandramati¹, Neeraj Sidharthan², Sasidharan Ponthenkandath¹

Affiliations

¹ Division of Neonatology.
² Pediatric Hematology, Amrita Institute of Medical Sciences, Amrita University, Amrita Viswavidyapeetham, Kochi, Kerala, India.

PMID: 32149866
DOI: 10.1097/MPH.0000000000001777

Abstract

The authors are reporting a case of autoimmune lymphoproliferative syndrome in a newborn who presented with massive hepatosplenomegaly, thrombocytopenia, and anemia at birth. Antenatal ultrasound revealed a fetus with hepatosplenomegaly. The infant was treated with steroids and sirolimus and is doing well at 4 years of age. This is the first case report of autoimmune lymphoproliferative syndrome presenting as hepatosplenomegaly during fetal life.

Publication types

Case Reports
Review

MeSH terms

Antibiotics, Antineoplastic / therapeutic use
Autoimmune Lymphoproliferative Syndrome / complications
Autoimmune Lymphoproliferative Syndrome / drug therapy
Autoimmune Lymphoproliferative Syndrome / pathology*
Female
Hepatomegaly / complications
Hepatomegaly / drug therapy
Hepatomegaly / pathology*
Humans
Infant, Newborn
Prognosis
Sirolimus / therapeutic use*
Splenomegaly / complications
Splenomegaly / drug therapy
Splenomegaly / pathology*
Thrombocytopenia / complications
Thrombocytopenia / drug therapy
Thrombocytopenia / pathology*

Substances

Antibiotics, Antineoplastic
Sirolimus