Tuberculous Spondylitis Caused by Intravesical Bacillus Calmette-Guerin Therapy

Intern Med. 2020;59(5):733-737. doi: 10.2169/internalmedicine.3288-19. Epub 2020 Mar 1.

Abstract

A 74-year-old man underwent intravesical bacillus Calmette-Guerin (BCG) therapy for bladder cancer and later presented with lower left back pain. Magnetic resonance imaging of the spine showed high signal intensity, diagnosed as a cystic lesion in the epidural and bilateral intestinal psoas muscle. A computed tomography-guided needle biopsy and histological examination revealed bacteria from the family Mycobacteriaceae, and Mycobacterium bovis was identified using multiplex polymerase chain reaction. If lower back pain appears in a patient who has undergone BCG therapy, it is necessary to test for tuberculous spondylitis. In addition, QuantiFERON is useful for the differential diagnosis of M. bovis BCG infection.

Keywords: Mycobacterium bovis; bacillus Calmette-Guerin; tuberculous spondylitis.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / adverse effects*
  • Administration, Intravesical
  • Aged
  • Antineoplastic Agents, Immunological / administration & dosage
  • Antineoplastic Agents, Immunological / adverse effects*
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / adverse effects*
  • Humans
  • Image-Guided Biopsy
  • Magnetic Resonance Imaging / adverse effects
  • Male
  • Mycobacterium bovis
  • Spondylitis / chemically induced*
  • Tomography, X-Ray Computed / adverse effects
  • Tuberculosis, Spinal / chemically induced*
  • Urinary Bladder Neoplasms / drug therapy*

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents, Immunological
  • BCG Vaccine