The morphology, self-assembly, and host-guest properties of cellulose nanocrystals surface grafted with cholesterol

Zhaleh Pourmoazzen; Hasan Sadeghifar; Jiachuan Chen; Guihua Yang; Kai Zhang; Lucian Lucia

doi:10.1016/j.carbpol.2020.115840

The morphology, self-assembly, and host-guest properties of cellulose nanocrystals surface grafted with cholesterol

Carbohydr Polym. 2020 Apr 1:233:115840. doi: 10.1016/j.carbpol.2020.115840. Epub 2020 Jan 8.

Authors

Zhaleh Pourmoazzen¹, Hasan Sadeghifar², Jiachuan Chen³, Guihua Yang⁴, Kai Zhang³, Lucian Lucia⁵

Affiliations

¹ Department of Forest Biomaterials, North Carolina State University, Box 8005, Raleigh, NC 27695-8005, USA.
² R&D Laboratory, Hollingsworth & Vose (H&V), West Groton, MA 01452, USA; Department of Forest Biomaterials, North Carolina State University, Box 8005, Raleigh, NC 27695-8005, USA. Electronic address: hasan.sadeghifar@hovo.com.
³ State Key Laboratory of Biobased Materials & Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan, 250353, China.
⁴ State Key Laboratory of Biobased Materials & Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan, 250353, China. Electronic address: ygh@qlu.edu.cn.
⁵ State Key Laboratory of Biobased Materials & Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan, 250353, China; Department of Chemistry, North Carolina State University, Box 8204, Raleigh, NC 27695-8204, USA; Department of Forest Biomaterials, North Carolina State University, Box 8005, Raleigh, NC 27695-8005, USA. Electronic address: lalucia@ncsu.edu.

PMID: 32059892
DOI: 10.1016/j.carbpol.2020.115840

Abstract

Cellulose nanocrystals (CNC) were prepared using acid hydrolysis of cellulose fiber. The CNC modified topo-chemically by grafting of bulky cholesterol moieties which changed subsequent morphology, thermal behavior, lyotropic crystalline properties, and host-guest release behavior. Bond formation between the cellulose nanocrystals surfaces and cholesterol was confirmed by FT-IR and solid-state NMR. The product indicated strong hydrophobic characteristics with an ordered chiral nematic self-assembly. This novel biomaterials were exploited through uptake of folic acid as part of a preliminary host-guest system. The guest molecule released as a function of physiologically relevant pHs was examined.

Keywords: Cellulose nanocrystals; Cholesterol; Drug release; Hydrophobicity; Topochemistry.

MeSH terms

Cellulose / analogs & derivatives*
Cellulose / chemical synthesis
Cholesterol / analogs & derivatives*
Cholesterol / chemical synthesis
Drug Carriers / chemical synthesis
Drug Carriers / chemistry*
Drug Liberation
Folic Acid / chemistry
Gossypium / chemistry
Hydrophobic and Hydrophilic Interactions
Nanoparticles / chemistry*

Substances

Drug Carriers
Cellulose
Folic Acid
Cholesterol