Rhino-Orbito-Cerebral Mucormycosis in Diabetic Disease Mucormycosis in Diabetic Disease

J Craniofac Surg. 2020 Jun;31(4):e321-e324. doi: 10.1097/SCS.0000000000006191.

Abstract

The authors present their experience about clinical evidences that include patients with an untreated diabetes who developed rhino-orbito-cerebral mucormycosis (ROCM). They were treated with endoscopic sinus surgery and medical treatment with intravenous, intradural therapy, and sinus washes with amphotericin B. The ROCM is a disease with a rapid evolution and an increase in mortality rate, especially if the fungus enters the cranial cavity. Therefore, it would be necessary in all diabetic patients with sinus symptoms, headaches, visual changes, suspect a mucormycosis, and perform a careful radiology assessment and a nasal endoscopy. Often, despite an early diagnosis and rapid treatment for ROCM, it is not possible to stem the disease, which ends with the patient's death.

MeSH terms

  • Aged
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Diabetes Complications*
  • Diabetes Mellitus
  • Endoscopy
  • Humans
  • Male
  • Middle Aged
  • Mucormycosis / complications
  • Mucormycosis / drug therapy
  • Mucormycosis / surgery*
  • Orbital Diseases / complications
  • Orbital Diseases / drug therapy
  • Orbital Diseases / surgery*
  • Paranasal Sinus Diseases / complications
  • Paranasal Sinus Diseases / drug therapy
  • Paranasal Sinus Diseases / surgery*

Substances

  • Antifungal Agents
  • Amphotericin B