A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor

Risk Anal. 1988 Sep;8(3):383-92. doi: 10.1111/j.1539-6924.1988.tb00502.x.

Abstract

We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinogens
  • Cocarcinogenesis*
  • Humans
  • Models, Statistical*
  • Neoplasms / etiology
  • Risk*
  • Stochastic Processes

Substances

  • Carcinogens