Br Med J. 1977 Feb 12;1(6058):420-2.

Successful bone marrow transplant for Fanconi's anaemia.

Barrett AJ, Brigden WD, Hobbs JR, Hugh-Jones K, Humble JG, James DC, Retsas S, Rogers TR, Selwyn S, Sneath P, Watson JG.

Abstract

A 15-year-old boy with Fanconi's anaemia, who required four units of blood each month, received a bone marrow graft from his 9-year-old brother, who has HLA identical and compatible on mixed lymphocyte reaction. Considerable immunosuppression was used and bacterial infection was prevented by vigorous decontamination in a Vickers-Trexler isolator. After the graft the patient's blood counts remained satisfactory for nine months, but it took six months before qualitative immune function was normal.

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Successful bone marrow transplant for Fanconi's anaemia.

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