Current Development on Chitosan-based Antimicrobial Drug Formulations for the Wound Healing

Curr Drug Discov Technol. 2020;17(4):534-541. doi: 10.2174/1570163817666200123122532.

Abstract

Background: Derived from polyose, chitosan is an outstanding natural linear polysaccharide comprised of random arrangement of β-(1-4)-linked D-Glucosamine and N-acetyl-DGlucosamine units.

Objective: Researchers have been using chitosan as a network forming or gelling agent with economically available, present polyose, low immunogenicity, biocompatibility, non-toxicity, biodegradability, protects against secretion from irritation and don't suffer the danger of transmission animal infective agent.

Methods: Furthermore, recent studies gear up the chitosan used in the development of various biopharmaceutical formulations, including nanoparticles, hydrogels, implants, films, fibers, etc. Results: These formulations produce potential activities as antimicrobials, cancer treatment, medical aid, and wound healing, controlled unleash device or drug trigger retarding device and 3DBiomedical sponge, etc. Conclusion: The present article discusses the development of various drug formulations utilizing chitosan as biopolymers for the repairing of broken tissues and healing in case of wound infection.

Keywords: Natural linear polysaccharide; chitosan; fibers; films; hydrogels; implant coatings; nanoparticles; wound care.

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacokinetics
  • Chitosan / chemistry*
  • Disease Models, Animal
  • Drug Carriers / chemistry*
  • Drug Compounding / methods
  • Humans
  • Hydrogels / chemistry
  • Macrophage Activation / drug effects
  • Nanoparticles / chemistry
  • Skin / drug effects
  • Skin / injuries*
  • Skin / metabolism
  • Skin / microbiology
  • Skin Absorption / drug effects
  • Wound Healing / drug effects*
  • Wound Healing / immunology

Substances

  • Anti-Bacterial Agents
  • Drug Carriers
  • Hydrogels
  • Chitosan