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    Acta Chem Scand B. 1988 Jul;42(6):403-7.

    Identification and analysis of a degradation product of the glucocorticoid desonide in ointment.

    Nguyen TT, Kringstad R, Aasen AJ, Rasmussen KE.

    Pharmaceutical Quality Assurance, Apothekernes Laboratorium A.S., Oslo, Norway.

    The major degradation product of desonide in a pharmaceutical ointment formulation has been shown to be identical with the C-17-carboxylic acid obtained on oxidative cleavage of the alpha-ketol group of desonide with alkaline hydrogen peroxide. The pKa value of this acid has been estimated from chromatographic data.

    PMID: 3195294 [PubMed - indexed for MEDLINE]

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